Solutions to nourish
mind and brain

From sleep and mood, to mental focus, clarity and agility, Biotis™ Brain health offers supporting solutions.

Healthy mind, healthy body

The social taboos that once surrounded mental health are fast disappearing, as consumers recognise the importance of mental wellbeing and its link with overall health.

In an increasingly uncertain world, people are more and more aware that an inability to relax and unwind is something that can impact their health, beyond simply influencing mood and energy levels. 57% of consumers say that they suffer from feelings of stress1, and as they become more educated about the holistic nature of wellbeing, are actively seeking safe, natural ways to support their mental health, addressing issues such as stress, anxiety and sleep disruption.

Biotis™ Brain health is developing a spectrum of solutions for different aspects of mental and cognitive health. Solutions to help people’s moods and sleep patterns, to think more clearly and focus better, to age healthily and to become more resilient to the pressures of life.

1 FMCG Gurus Top Trend 5 – Re-evaluating Health Explored 2020.

SleepWell - Nourish your night

Introducing Biotis™

Biotis™ Brain health develops ingredients and solutions for sleep and mood, to mental focus, clarity and agility.
To support sleep, we developed Biotis™ SleepWell, a holistic solution for adults who want to improve their sleep quality in a natural way. Based on a formulation of prebiotics and protein, to help with falling asleep, sleeping through the night and waking up fresh.

Sleep, wellbeing and
quality of life

Consumers are more health conscious and recognise that all elements of their wellbeing are interconnected. They increasingly understand that nutrition, sleep and exercise are inextricably linked.

We humans spend up to one third of our life sleeping. On average, that amounts to a considerable 26 years. More surprisingly perhaps, we spend seven years trying to get to sleep.

Sleep is a basic human need, like eating and drinking, and is a hugely important factor in living a long, healthy and productive life.

The health and economic costs of poor sleep

Sleep deprivation is a serious issue. Because not enough sleep or poor-quality sleep can lead to all manner of health issues in both the short and longer term1.

Next-day negative effects can include lack of energy, clumsiness, impaired attention span and memory recall1.

Further down the line, sleep deprivation has been associated with many serious health problems, such as stress, anxiety, depression, obesity, diabetes, weakened immune system and lower life expectancy2.

1 Krause, 2017; 2 NSF,, 2020, NHS, 2018.

The demand for sleep aids and remedies is soaring

As sleep becomes one of the hot topics of the age, consumers are becoming more and more aware of how important it is to their health.

One in four (25%) say that they typically get less than five hours sleep in the average night. This is much lower than the recommended eight hours per day. Overall, nine in ten consumers have taken steps to try and improve their sleep patterns1.

1 FMCG Gurus Insights & Opportunities – Global Stress and Sleep Management 2020.

How the gut helps us to sleep well

Experts believe that the gut microbiome can affect our quality of sleep by disturbing our sleep-wake cycle, our circadian rhythm, and the hormones that regulate wakefulness and sleep1.

A recent study has shown that greater diversity of bacteria in the gut could improve sleep quality at night and alleviate sleepiness during the day2.

As world-leading experts in gut health, we’re developing solutions on the findings of solid scientific research.

1 Zhang et al., 2017, Benedict et al., 2016, Smith et al., 2019, Poroyko et al., 2016, Thompson et al., 2017; 2 Kate E Sprecher et al., 2019

Gut-brain axis

The evidence indicates that micro-organisms and circadian genes interact with each other via the gut-brain axis, and this could influence the sleep-wake cycle. A prebiotic3* such as BiotisTM GOS could play a role in the support of the gut microbiome, keeping it healthy, and in turn promoting better sleep4,5.

Friendly bacteria

Research shows that GOS may help with the growth of Lactobacillus and Bifidobacteria6 in the gut. Studies suggest that these friendly gut bacteria may reduce stress7,8 and anxiety symptoms9,10, which are thought to hamper a good night’s sleep.


Amino-acids from protein can encourage neurotransmitters, such as serotonin and melatonin, which are associated with the sleep-wake cycle. What’s more, they can act as building blocks to support processes that help us to recover well during the night so we feel fresh in the morning11.


Not having enough of the right micronutrients in your system can result in poor sleep quality12-13. The formula we are developing helps to supplement essential micronutrients which in turn may encourage restful sleep14-17.

Consumer Insight

At FrieslandCampina Ingredients, we’re leading worldwide research into natural, non-addictive sleep solutions. We have established a dedicated team to create a compelling product range that will appeal to consumers and dovetail with their lifestyles.

We consider sleep as part of the ‘golden triangle’ of human health. It’s the balance of nutritious food, regular exercise and sleeping well that is the key to living a long and healthy life. With decades of experience in developing high-performance nutritional products for adults, infants and elite athletes, we’re now turning our attention to products that can help all of us to sleep better.

Research by the Biotis™ team identified that people are looking for natural solutions that fit with their lifestyles and evening routine. Our studies found a clear preference for a night-time shot1.

1 Online questionnaire by FCI, Biotis™ team, 2018 (on request, not publicly available).

Biotis™ SleepWell — a holistic approach to sleep

We’ve created and piloted a unique, natural solution; one that provides a threefold benefit to people who want to improve their sleep.

Biotis™ SleepWell’s unique, natural formula offers the triple benefit of helping people to fall asleep naturally, to sleep through the night and to wake up feeling refreshed. This threefold action of proteins, micronutrients and BiotisTM GOS prebiotic1* means that they are buying a superior, holistic sleep product. It is safe, effective and non-addictive.

1 ISAPP (International Scientific Association for Probiotics and Prebiotics), Gibson et al., 2017: *Substrates that are selectively utilized by host microorganisms conferring a health benefit.

Want to know more about Biotis™ Brain health? Let’s start a conversation